USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: PP2AB_HUMAN USC-OGP 2-DE database:  PP2AB_HUMAN PP2AB_HUMAN General information about the entry View entry in simple text format Entry name PP2AB_HUMAN Primary accession number P62714 Secondary accession number(s) P11082 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; Short=PP2A-beta; EC=3.1.3.16;. Gene name Name=PPP2CB Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0756: pI=5.15; Mw=32720 Cross-references UniProtKB/Swiss-Prot P62714; PP2AB_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PP2AB_HUMAN Primary accession number P62714 Secondary accession number(s) D3DSV4 P11082 Q6FHK5 Sequence was last modified on  July 19, 2004 (version 1) Annotations were last modified on  March 15, 2017 (version 140) Name and origin of the protein Description RecName: Full=Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; Short=PP2A-beta; EC=3.1.3.16; Gene name Name=PPP2CB Encoded on Name=PPP2CB Keywords Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Hydrolase; Manganese; Metal-binding; Methylation; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X12656; CAA31183.1; -; mRNA EMBL CR541747; CAG46547.1; -; mRNA EMBL J03805; AAB38020.1; -; mRNA EMBL CH471080; EAW63434.1; -; Genomic_DNA EMBL CH471080; EAW63435.1; -; Genomic_DNA EMBL CH471080; EAW63436.1; -; Genomic_DNA EMBL BC012022; AAH12022.1; -; mRNA EMBL M60484; AAA36467.1; -; Genomic_DNA CCDS CCDS6079.1; -; . PIR B37135; PAHU2B; . RefSeq NP_001009552.1; NM_001009552.1; . UniGene Hs.491440; -; . ProteinModelPortal P62714; -; . SMR P62714; -; . BioGrid 111508; 141; . DIP DIP-42325N; -; . IntAct P62714; 130; . MINT MINT-1348293; -; . STRING 9606.ENSP00000221138; -; . DrugBank DB00163; Vitamin E; . DEPOD P62714; -; . iPTMnet P62714; -; . PhosphoSitePlus P62714; -; . SwissPalm P62714; -; . BioMuta PPP2CB; -; . DMDM 50402236; -; . OGP P62714; -; . REPRODUCTION-2DPAGE IPI00429689; -; . EPD P62714; -; . MaxQB P62714; -; . PaxDb P62714; -; . PeptideAtlas P62714; -; . PRIDE P62714; -; . DNASU 5516; -; . Ensembl ENST00000221138; ENSP00000221138; ENSG00000104695; . GeneID 5516; -; . KEGG hsa:5516; -; . UCSC uc003xik.4; human; . CTD 5516; -; . DisGeNET 5516; -; . GeneCards PPP2CB; -; . HGNC HGNC:9300; PPP2CB; . HPA CAB018600; -; . HPA HPA043236; -; . MIM 176916; gene; . neXtProt NX_P62714; -; . OpenTargets ENSG00000104695; -; . PharmGKB PA33664; -; . eggNOG KOG0371; Eukaryota; . eggNOG COG0639; LUCA; . GeneTree ENSGT00550000074618; -; . HOGENOM HOG000172696; -; . HOVERGEN HBG000216; -; . InParanoid P62714; -; . KO K04382; -; . OMA MDDKTFT; -; . OrthoDB EOG091G0B6S; -; . PhylomeDB P62714; -; . TreeFam TF105559; -; . Reactome R-HSA-113501; Inhibition of replication initiation of damaged DNA by RB1/E2F1; . Reactome R-HSA-1295596; Spry regulation of FGF signaling; . Reactome R-HSA-163685; Integration of energy metabolism; . Reactome R-HSA-163767; PP2A-mediated dephosphorylation of key metabolic factors; . Reactome R-HSA-180024; DARPP-32 events; . Reactome R-HSA-195253; Degradation of beta-catenin by the destruction complex; . Reactome R-HSA-196299; Beta-catenin phosphorylation cascade; . Reactome R-HSA-198753; ERK/MAPK targets; . Reactome R-HSA-202670; ERKs are inactivated; . Reactome R-HSA-2465910; MASTL Facilitates Mitotic Progression; . Reactome R-HSA-2467813; Separation of Sister Chromatids; . Reactome R-HSA-2500257; Resolution of Sister Chromatid Cohesion; . Reactome R-HSA-389513; CTLA4 inhibitory signaling; . Reactome R-HSA-432142; Platelet sensitization by LDL; . Reactome R-HSA-4641262; Disassembly of the destruction complex and recruitment of AXIN to the membrane; . Reactome R-HSA-5339716; Misspliced GSK3beta mutants stabilize beta-catenin; . Reactome R-HSA-5358747; S33 mutants of beta-catenin aren't phosphorylated; . Reactome R-HSA-5358749; S37 mutants of beta-catenin aren't phosphorylated; . Reactome R-HSA-5358751; S45 mutants of beta-catenin aren't phosphorylated; . Reactome R-HSA-5358752; T41 mutants of beta-catenin aren't phosphorylated; . Reactome R-HSA-5467337; APC truncation mutants have impaired AXIN binding; . Reactome R-HSA-5467340; AXIN missense mutants destabilize the destruction complex; . Reactome R-HSA-5467348; Truncations of AMER1 destabilize the destruction complex; . Reactome R-HSA-5663220; RHO GTPases Activate Formins; . Reactome R-HSA-5673000; RAF activation; . Reactome R-HSA-5675221; Negative regulation of MAPK pathway; . Reactome R-HSA-6804757; Regulation of TP53 Degradation; . Reactome R-HSA-6811558; PI5P; PP2A and IER3 Regulate PI3K/AKT Signaling; . Reactome R-HSA-68877; Mitotic Prometaphase; . Reactome R-HSA-69231; Cyclin D associated events in G1; . Reactome R-HSA-69273; Cyclin A/B1 associated events during G2/M transition; . Reactome R-HSA-70171; Glycolysis; . SIGNOR P62714; -; . ChiTaRS PPP2CB; human; . GeneWiki PPP2CB; -; . GenomeRNAi 5516; -; . PRO PR:P62714; -; . Proteomes UP000005640; Chromosome 8; . Bgee ENSG00000104695; -; . CleanEx HS_PPP2CB; -; . ExpressionAtlas P62714; baseline and differential; . Genevisible P62714; HS; . GO GO:0000775; C:chromosome; centromeric region; IEA:UniProtKB-SubCell GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005634; C:nucleus; IEA:UniProtKB-SubCell; . GO GO:0000159; C:protein phosphatase type 2A complex; TAS:UniProtKB; . GO GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell; . GO GO:0046872; F:metal ion binding; IEA:UniProtKB-KW; . GO GO:0004722; F:protein serine/threonine phosphatase activity; IEA:Ensembl; . GO GO:0008637; P:apoptotic mitochondrial changes; IEA:Ensembl; . GO GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:Ensembl; . GO GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl; . GO GO:0006470; P:protein dephosphorylation; TAS:UniProtKB; . GO GO:0010468; P:regulation of gene expression; IEA:Ensembl; . GO GO:0046677; P:response to antibiotic; IEA:Ensembl; . GO GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl; . GO GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl; . Gene3D 3.60.21.10; -; 1; . InterPro IPR004843; Calcineurin-like_PHP_ApaH; . InterPro IPR029052; Metallo-depent_PP-like; . InterPro IPR006186; Ser/Thr-sp_prot-phosphatase; . Pfam PF00149; Metallophos; 1; . PRINTS PR00114; STPHPHTASE; . SMART SM00156; PP2Ac; 1; . SUPFAM SSF56300; SSF56300; 1; . PROSITE PS00125; SER_THR_PHOSPHATASE; 1; .

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• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
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• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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